Renal fibrosis is accompanied by a loss of renal epithelial cells due to up-regulation of angiotensin II (Ang II) type I receptor (AT1R) expression, down-regulation of angiotensin 1-7 (Ang1-7)/MasR, activation of transforming growth factor-β1 (TGF-β1), microRNA (miR) under- or overexpression, inflammation, epithelial-to-mesenchymal transition, and fibroblast to myofibroblast trans-differentiation (2). The gene discussed is AGT; the disease is renal fibrosis.