ADAMTS13 and ischemic stroke: The SNP has been associated witha reduced risk of ischemic stroke.9 The variant g.41635A>G(rs4962153), located in intron 28, has been associated with increased risk ofischemic stroke,9 reduced ADAMTS13 antigen and activity levels8 and increasedVWF antigen levels.10 The variant c.2699C>T (rs685523) is located in exon 21in one of the thrombospondin type 1 repeats, resulting in a missense mutation atposition 900 with the amino acid shift from alanine to valine (A900V).