Low ADAMTS13 and high VWF levels have beenassociated with AF and left atrial remodeling.19,20 As the observedassociation of the ADAMTS13 c.1342C>G variant with previous cerebral ischemicevents and AF was not accompanied by lower ADAMTS13 or higher VWF levels in ourstudy, the mechanisms behind these observations are unclear. This evidence concerns the gene ADAMTS13 and atrial fibrillation.