The main findings in our study in patients with CCS were that the ADAMTS13 41635A-allele associated with higher VWF levels and a higher VWF/ADAMTS13 antigen ratio.Patients with the ADAMTS13 1342 G-allele presented with higher frequency of AF andcerebral ischemic events at baseline, and a tendency towards higher clinicalendpoint rate after two years in the heterozygous group. Here, ADAMTS13 is linked to atrial fibrillation.