In our previous study,27 PWY-7357 was associated with blood protein levels of the paraoxonases family 3 (PON3) and plasminogen activator inhibitor (PAI), and the levels of both PON3 and PAI are mainly determined by gut microbiome factors and are associated with increased glucose level, insulin level, and diabetes risk.27,28. Here, PON3 is linked to diabetes mellitus.