Previous studies have revealed that proliferative cancer cells can activate hypoxia-inducible factor to upregulate several protein expressions and functions, such as glucose transporter (GLUT) to increase glucose uptake, lactate dehydrogenase A (LDHA) to increase lactate production, and pyruvate dehydrogenase kinase (PDK) to inhibit mitochondrial oxidative phosphorylation [7, 8]. The gene discussed is LDHA; the disease is cancer.