For tumor cells, interactions between tumor cells and T cell subsets via CXCL16-CXCR6, CCL20-CXCR3, PVR-CD226, and NECTIN2-CD226 decreased after treatment, indicating that recruitment and co-stimulation interactions between tumor cells and T cells were reduced by treatment, which is similar with the decreased activities in recruitment and stimulatory interactions were seen for macrophages. Here, CXCR6 is linked to neoplasm.