Subsequently, univariate Cox and LASSO Cox regression analysis were conducted on these 106 genes and the HCC data in TCGA, then 11 optimal genes were selected to build a Risk score, including HMMR, MCM6, TPX2, KIF20A, CCL20, RGS2, NUSAP1, FABP5, FZD6, PBK, and STK39. The gene discussed is PBK; the disease is hepatocellular carcinoma.