In cluster1, KEGG analysis showed that the DEPs after DBS intervention were mainly concentrated in multiple neuropsychiatric disease pathways, including PD, HD, ALS, and AD, which involved the DEPs encoded by four genes (NDUFA7, LOC690675, PLCB1, and UQCRFS1). Here, PLCB1 is linked to amyotrophic lateral sclerosis.