GLI2 and neoplasm: For example, previous studies have shown that SPOP is differentially detected in gastric cancer tissues and adjacent gastric tissues that SPOP was overexpressed in the cytoplasm and nuclear of adjacent gastric mucosa epithelium cells but rarely expressed in gastric cancer cells.Further study provide evidence that SPOP functions as a tumor suppressor in different gastric cancer cell lines and through inhibiting Hh/Gli2 pathway, and the possible molecular mechanism of Gli2 stability regulated by SPOP [17].