The joint effects of APOE4 and high school or less educational attainment (HR 3.61, 95% CI: 1.51–8.61, p = 0.003), hypertension (HR = 2.46, 95% CI: 1.28–4.73, p = 0.007), elevated depressive symptoms (HR = 5.09, 95% CI: 2.59–10.02, p < 0.001), hearing loss (HR = 3.44, 95% CI: 1.87–6.33, p < 0.001), vision impairment (HR = 5.14, 95% CI: 2.31–11.43, p < 0.001), smoking (HR = 2.35, 95% CI: 1.24–4.47, p = 0.009), and obesity (HR = 3.80, 95% CI: 2.11–6.85, p < 0.001) were associated with incident CIND in separate models. This evidence concerns the gene APOE and Obesity.