The high-risk subgroup had significantly lower infiltration of B cells, CD8+ T cells, dendritic cells, neutrophils, NK cells, macrophages, mast cells, Plasmacytoid dendritic cells, T helper cells, T follicular helper cells, Th1 cells, Th2 cells, tumor-infiltrating lymphocytes, and regulatory T cells than that of the low-risk subgroup (P < 0.001; Fig. 7A). This evidence concerns the gene CD8A and neoplasm.