The remaining transcription factors, such as YY2, TFAP2A, GATA2, MEF2A, and SREBF1, are implicated in positive and negative regulation of the transcription of several target genes, branchiooculofacial syndrome (BOFS), development and proliferation of hematopoietic and endocrine cell lineages, muscle development, neuronal differentiation, cell growth control, and apoptosis as well as sterol biosynthesis33–36. Here, YY2 is linked to Branchio-oculo-facial syndrome.