HIPK1 and cancer: Validating our multi-omic platform and target identification analyses, HIPK1 pooled KO result in a striking reduction of cancer stem cell functions in SU_MB002 (Supplementary Fig. 10a–c) and HD-MB03 (Supplementary Fig. 10d–f) (G3 MB cell lines), whose stem cell properties are rescued with HIPK1 overexpression after MSI1 knockdown (Supplementary Fig. 10g), while sparing human NSC (Supplementary Fig. 12a–d).