MSI1 and neoplasm: The RRA results are further supported by transcriptomic analyses of primary tumor specimens6,85, which reveal a positive correlation between MSI1 and HIPK1 expression in MB (Fig. 4b, Supplementary Fig. 9b) highlighting the importance of investigating not only the genomic and transcriptomic landscape, but the post-transcriptional changes when studying the functional role of an RNA binding protein.