CHD6 and colorectal carcinoma: Consistent with CHD6 mRNA upregulation, immunohistochemistry (IHC) staining of a panel of 104 CRC and 76 corresponding normal tissue specimens (tissue microarray (TMA)) showed that CHD6 protein expression is significantly higher in CRC than in adjacent normal tissue (66 of 76 paired samples (86.8%)) (Fig. 1b).