TNF and appendicitis: As expected, this unbiased PheWAS identified significant associations of rs8736 with liver injury (e.g., elevated liver enzymes), inflammation and immune-related traits including blood cell traits (myeloid cell count, platelet crit (also called platelet mass) and count, neutrophil count and granulocyte count), and nominally with multiple other traits including TNF-α, periodontitis, appendicitis, and deep vein thrombosis (Fig. 7s and Supplementary Data 1).