Notably, LY6D expression is also enriched in the well-differentiated human SCC cluster and marks the overlap between human BCC and SCC scRNA-Seq data and the IFE suprabasal cells of human foreskin scRNA-Seq data, further drawing a parallel to the basosquamous cellular state observed in naive human BCCs (Supplementary Fig. 2a–g)16,17. This evidence concerns the gene LY6D and skin basal cell carcinoma.