According to the results obtained, it can be concluded that, on the one hand, RBCK1 can promote tumor progression, such as migratory cloning of ER-positive breast cancer; on the other hand, RBCK1 can impact the activity of the hypoxia-inducible factor HIF1α signaling pathway by increasing the expression of HIF1α. The gene discussed is HIF1A; the disease is neoplasm.