BDNF and cyclic hematopoiesis: Given that CH alters Ca2+ influx into neurons of the cortex and hippocampus of developing rats [26, 27], which is involved in the inactivation of CaMKIV [28, 29], it is assumed that the EGR3/BDNF axis may be affected by the dysregulation of CaMKIV, as the calmodulin-dependent protein kinase is proved to be active in the regulation of EGRs [30].