CCND1 and neoplasm: To determine if the combination of MakA and ISA-2011B induces stable inhibition of tumour cell proliferation, HCT8 cells were treated with (i) MakA, (ii) ISA-2011B, or (iii) a combination of MakA and ISA-2011B and stained for cell proliferation markers, cyclin D1 or Ki67 (Fig. 5B–D).