ADRB3 and obesity due to melanocortin 4 receptor deficiency: This is significant given the recent reports that low lipolytic activity in the subcutaneous WAT predicts future risks of impaired glucose homeostasis in women,59 and downregulation of β3-AR leads to adipocyte catecholamine resistance in obesity.60 Determining the degree to which oral supplementation of linoleic acid increases the beige progenitor cell pool in humans is also of paramount importance.