A few examples include: RQ77: “Is immunotherapy helpful for the treatment of DTD?” RQ30: “Is inflammation a causal risk factor for DTD, if so, could it be a new treatment target?” and RQ92: “In patients with DTD, does a raised blood CRP (C-reactive protein) level predict response to catecholamine antidepressants?” This area received growing interest over the past few years, with emerging evidence indicating raised inflammation levels in more treatment-resistant patients with depression [40-42]. Here, CRP is linked to major depressive disorder.