Expression of the gene regulated on activation, T cell expressed, and secreted (RANTES; Ccl5), which is associated with severe liver fibrosis (43), was also significantly upregulated in HFHC-fed Dpp4–/– mice (Figure 5G), whereas no changes in Mcp-1 (Ccl2) or Eotaxin (Ccl11) gene expression were noted (Figure 5, H and I). The gene discussed is CCL2; the disease is Hepatic fibrosis.