In mice, DPP4is decrease liver fibrosis (70, 71); however, this was not recapitulated by genetically eliminating Dpp4 as Picrosirius red staining revealed a trend toward increased fibrosis, and expression of Col1a1 and Col3a1 was increased in Dpp4–/– mice. This evidence concerns the gene COL3A1 and Hepatic fibrosis.