Consistent with its role in NAFLD progression (42), Ip-10 (Cxcl10) gene expression was significantly upregulated in HFHC-fed Dpp4–/– mice compared with controls but unchanged in SLD-fed mice and HFHC-fed Dpp4hep–/– mice compared with controls (Figure 5F). Here, DPP4 is linked to metabolic dysfunction-associated steatotic liver disease.