PNPLA2 and hepatocellular carcinoma: Although the levels of other lipid droplet–surrounding factors, including ATGL, HSL/phosphorylated HSL, GCI-58, and CIDEA–C, did not significantly change, the de novo lipogenic enzyme ACC decreased slightly, while the ratio of phosphorylated ACC/total ACC increased upon blockage of CES1, suggesting that lipogenesis was also affected by inhibition of CES1 in HCC.