CES1 and hepatocellular carcinoma: Notably, while reexpression of CES1 efficiently reduced the cell apoptosis induced by cisplatin in CES1-KO cells, blocking the activity of SCD by its specific inhibitor MF348 significantly abolished the rescuing effect of CES1 reexpression (Figure 6, I and J), suggesting the key role of SCD in CES1-mediated HCC cell growth.