IFNA1 and COVID-19: This analysis provided evidence that severe tissue damage in these patients with COVID-19 involved an ensemble of interacting and proliferating immune cells in which myeloid cells such as inflammatory monoMac and DCs were activated by TLR-mediated signaling, expressed IL-1 and IFN-α, and presented antigen to cytotoxic lymphocytes driving the production of IFN-γ and a specific cassette of chemokines and cytokines.