Over time, Cxcr3 and Klrg1 were progressively decreased on tumor-specific T cells infiltrating PDA and these Cxcr3-Klrg1- T cells co-expressed PD-1 and Lag-3, markers that identify TEX cells defective in IFNγ production [8]. The gene discussed is PDCD1; the disease is Patent ductus arteriosus.