CD40 and Patent ductus arteriosus: In stromal-rich regions that lacked CK + tumor cells, 1045 T cells + CD40 agonist increased Cxcl9/Cxcl10 expression by macrophage and 1045 T cells appeared to colocalize with the Cxcl9 + macrophage in these stromal regions (Supplementary Fig. 5C), similar to our results in resected human PDA [37].