UBA5 and Becker muscular dystrophy: Furthermore, the expression of UFC1 is also up-regulated in skeletal myocytes differentiated from induced pluripotent stem cells derived from familial ALS (C9ORF72 mutations) (Lynch et al., 2021), and the expression of UBA5, the E1 ligase for UFMylation has recently been associated with Becker muscular dystrophy (Xu et al., 2021).