To explore the effects of DUXAP10 on gefitinib resistance in lung adenocarcinoma cells, we transfected PC9/GR cells with DUXAP10-specific siRNAs to downregulate its expression, and the pcDNA3.1-DUXAP10 vector was transfected into PC9 cells to upregulate its expression. Here, DUXAP10 is linked to lung adenocarcinoma.