In MDD, high serum CRP levels have been associated with anterior cingulate cortex (ACC) and entorhinal thinning (Green et al., 2021; Meier et al., 2016) and microstructural and functional connectivity changes in the precuneus, posterior cingulate cortex (PCC) and medial prefrontal cortex (Kitzbichler et al., 2021). The gene discussed is CRP; the disease is major depressive disorder.