CRP and major depressive disorder: Furthermore, patients with psoriasis and other disorders with psychosomatic features exhibit high levels of alexithymia (marked by an inability to recognize and describe emotions) (De Berardis et al., 2007; Kleyn et al., 2020), which generally increases vulnerability to depression and suicidality, and has been associated with elevated serum C-reactive protein (CRP) among psychiatric patients (De Berardis et al., 2017, 2020).