In the tumor microenvironment, COX-2 decreases the apoptosis of tumor cells by upregulating the expression of the anti-apoptotic protein survivin [10], impairing cell adhesion by downregulating E-cadherin [11], and promoting epithelial to mesenchymal transition (EMT) by upregulating miR-526b expression [12]. The gene discussed is CDH1; the disease is neoplasm.