Our PPI network presented a direct connection of PTGS2 with CAV-1 and highlighted topologically relevant nodes in both chromosomes, revealing that the regulation of COX-2 in NB tumors may be based on complex interactions among proteins coded in Ch 7q11.23-q36.3 and Ch 11q13.4-q25 (Figure 3). Here, C4B is linked to neuroblastoma.