Overall, the four E2F-related genes, CDKN2C, CDKN3, RACGAP1, and RRM2, identified in this study, were found to play crucial roles in the progression of PCa, and the E2F-related gene signature based on the four identified genes exhibited good performance in predicting the RFS of PCa patients. This evidence concerns the gene RRM2 and posterior cortical atrophy.