To explore the role of the E2F pathway in biochemically recurrent PCa, we used LASSO regression to identify RFS-related genes, and four genes, CDKN2C, CDKN3, RACGAP1, and RRM2, were identified, which were negatively associated with RFS in PCa patients in the MSKCC cohort. The gene discussed is RACGAP1; the disease is posterior cortical atrophy.