Subsequently, LASSO and Cox regression analyses identified four E2F-related genes, CDKN2C, RACGAP1, cyclin-dependent kinase inhibitor 3 (CDKN3), and ribonucleotide reductase small subunit M2 (RRM2) (Fig. 2A, B) that were negatively associated with RFS in PCa patients (Fig. 2C–F). This evidence concerns the gene CDKN3 and posterior cortical atrophy.