RRM2 and posterior cortical atrophy: Subsequently, LASSO and Cox regression analyses identified four E2F-related genes, CDKN2C, RACGAP1, cyclin-dependent kinase inhibitor 3 (CDKN3), and ribonucleotide reductase small subunit M2 (RRM2) (Fig. 2A, B) that were negatively associated with RFS in PCa patients (Fig. 2C–F).