To explore the role of the E2F pathway in biochemically recurrent PCa, we used LASSO regression to identify RFS-related genes, and four genes, CDKN2C, CDKN3, RACGAP1, and RRM2, were identified, which were negatively associated with RFS in PCa patients in the MSKCC cohort. This evidence concerns the gene RRM2 and posterior cortical atrophy.