To characterize the role of the progranulin/EphA2 axis in mesothelioma, we initially analyzed the expression levels of progranulin in a panel of mesothelioma cell lines representative of the three major histologic subtypes, sarcomatoid (NCI-H2052, NCI-H2452), epithelioid (NCI-H28) and biphasic (MSTO-211H). Here, EPHA2 is linked to mesothelioma.