RYK and mesothelioma: As shown in Fig. 7C, neither cell exposure to the EGFR inhibitor nor cell treatment with progranulin significantly affected pFAK Y397 levels, whereas RYK gene knock down led to a reduction of pFAK Y397 levels and to a lesser extent in total levels of FAK in both cell lines (Fig. 7C), pointing out an important role of RYK in modulating FAK activity in mesothelioma.