As shown in Fig. 7C, neither cell exposure to the EGFR inhibitor nor cell treatment with progranulin significantly affected pFAK Y397 levels, whereas RYK gene knock down led to a reduction of pFAK Y397 levels and to a lesser extent in total levels of FAK in both cell lines (Fig. 7C), pointing out an important role of RYK in modulating FAK activity in mesothelioma. The gene discussed is PTK2; the disease is mesothelioma.