Progranulin was upregulated in all mesothelioma cell lines as compared to immortalized cells derived from normal mesothelium (MeT-5A), with the highest expression levels in NCI-H2452, NCI-H28 and MSTO-211H, as assessed by immunoblot in cell lysates, conditioned media and ELISA assay (Fig. 1A-B). This evidence concerns the gene GRN and mesothelioma.