To further decipher the contribution of EphA2 in modulating the progranulin axis in mesothelioma, we generated MSTO-211H and NCI-H2052 cells with genetic deletion of EphA2 by CRISPR/Cas9 technology (Supplementary Fig. 1A-B) and compared the ability of GRN- and EphA2-KO cells to migrate and invade through matrigel [14, 18–20, 22, 24]. Here, GRN is linked to mesothelioma.