The increase in EGFR levels and activity might represent a homeostatic compensatory mechanism for progranulin loss in mesothelioma, which is reminiscent of the increase in expression of several neurotrophic receptors, including RTKs, molecules of the semaphorin-signaling pathway, Notch-related receptors and receptors belonging to the WNT signaling pathways, observed in progranulin-depleted neuronal cells [42]. This evidence concerns the gene GRN and mesothelioma.