MME and Alzheimer disease: The aim of the current study was to evaluate Aβ degradation capacity of the BBB-penetrant soluble NEP protein (sNEP-scFc-scFv8D3) and the BBB-penetrant mutated variant of NEP (muNEP-scFc-scFv8D3), both in vitro and in vivo using a transgenic mouse model of AD.