PKM and hepatocellular carcinoma: With respect to m6A modification and cancer aerobic glycolysis, it is reported that ALKBH5 enhances chemosensitivity of cells to cisplatin via glycolysis in bladder cancer [18], METTL3 overexpression enhances glycolysis metabolism and promotes tumor growth in HCC [19] and demethylase FTO can regulate PKM2 mRNA and promote its translation through m6A modification, thus promoting hepatocellular carcinoma tumorigenesis [20].