It is reported that in hepatocellular carcinoma, circ-KIAA1429 promoted the progression of HCC by inhibiting the degradation of Zeb1 mRNA through the m6A-YTHDF3-Zeb1 axis [22], and in our study, YTHDF3 promotes the expression of PFKL by inhibiting degradation of PFKL mRNA, thereby promoting progression of HCC. This evidence concerns the gene YTHDF3 and hepatocellular carcinoma.