Moreover, highly-expressed lysine-specific demethylase 5B can promote proliferation, migration, invasion and other malignant phenotypes of HCC cells through miR-448 /YTHDF3/ITGA6 (Integrin subunit alpha 6) axis in hepatocellular carcinoma, confirming that YTHDF3 plays an important role in the occurrence and development of HCC [14]. Here, KDM5B is linked to hepatocellular carcinoma.