Those associations have been explained by the accumulated biological experiment data that p53 protein encoded by IF-DBD TP53 mutations accumulate in the tumor cell nuclei through interfered MDM2-mediated ubiquitination, and DISRUPTED TP53 mutations result in non-sense mediated decay, or prematurely truncated mRNA, and thus null pattern of p53 IHC [22]. The gene discussed is MDM2; the disease is neoplasm.