Our present findings and these previous reports suggest that DNA hypermethylation of the gene body CpG island of ZC3H3 is present even from the precancerous NASH stage and participates in NASH-related multistage hepatocarcinogenesis via overexpression of ZC3H3, resulting in abnormal post-transcriptional regulation of various tumor-related genes. The gene discussed is ZC3H3; the disease is metabolic dysfunction-associated steatohepatitis.