Taken together, the results of GO and KEGG analyses suggested that the complement (C1QB, C1QC, C4BPA, and C4BPB) and coagulation (F13B, FGA, FGB, and FGG) pathways are the major pathways in which SDEPs are involved, and the dysregulated proteins of the complement and coagulation pathways may be potential molecular signatures for HCC. The gene discussed is FGA; the disease is hepatocellular carcinoma.