The malignant effect of the tumors resulted in weight loss in the GEM group being about 20%; however, in the PTK7-GEMs group only lost about 10% of their weight (Fig. 6F), with about 75% relative tumor growth inhibition, which was better than the GEM treatment group (55% tumor volume reduction) (Fig. 6C). This evidence concerns the gene PTK7 and neoplasm.