PTK7 and neoplasm: In addition, the maximum inhibition rate of PTK7-GEMs and GEM was about 85% on 5637 tumor cell line, while that of PTK7-GEMs toward normal bladder uroepithelial cells was lower than 45%; similar result was observed for the cell cycle and the apoptosis rate (Fig. 3D and E; Additional file 1: Fig. S14A and B).