PTK7 and steatosis: Meanwhile, the liver H&E staining analysis showed that both the GEM and LIBGEMs groups have varying degrees of hepatic cord loss, steatosis and sinusoid dilatation, while the PTK7-GEMs group showed a clear liver tissue structure with no obvious liver tissue damage (Additional file 1: Fig. S21A), Furthermore, no obvious structural injury in the main organs (Additional file 1: Fig. S21B - E) in all groups.