As with NASH, the immunosuppressive role of YAP during IRI was found to depend on its interaction with β-catenin, leading to inhibition of XBP1-mediated NLRP3 inflammasome activation and induction of the M2 reparative macrophage phenotype [121] (Fig. 5 B). This evidence concerns the gene NLRP3 and metabolic dysfunction-associated steatohepatitis.