Recently, Wang et al. [113] found a crucial link in liver macrophages between YAP activation and the expression of (erythroid-derived 2)-like 2 factor (NFE2L2, best known as Nrf2), the transcription factor considered as the “master switch” of intracellular redox homeostasis [114], during NASH development (Fig. 5 B). Here, NFE2L2 is linked to metabolic dysfunction-associated steatohepatitis.