As Hedgehog and YAP signaling are key pathways involved in controlling energy consumption and maintaining myofibroblastic properties, recently Bruschi et al. [140] investigated whether the I148M variant of the PNPLA3 gene could promote TGF-β- and leptin-induced liver fibrosis in primary HSC cells by impairing Hedgehog and YAP signaling. Here, PNPLA3 is linked to Hepatic fibrosis.