While in the studies by Song and Wang [109, 112], it was shown that YAP/TAZ activation in KCs promotes NASH progression to fibrosis by inducing transcription of inflammatory cytokine genes and M1/M2 polarization (Fig. 5 A), in the study by Wang et al. [113] it was found that Nrf2-dependent YAP activation in KCs attenuated disease progression and inflammation in NASH livers by inhibiting the NLRP3 inflammasome and promoting the M2 anti-inflammatory phenotype (Fig. 5 B). Here, NFE2L2 is linked to metabolic dysfunction-associated steatohepatitis.