ATG7 and carcinoma: Interestingly, the liver-specific double knockout of Atg7 and Yap in mice resulted in a phenotype with fewer liver changes than the single knockout of Atg7. While deletion of Atg7 caused the development of carcinoma due to hepatomegaly, lobular and portal inflammation, ductular reaction, steatosis, and fibrosis, all these pathological signs were significantly ameliorated by removal of Yap, resulting in less hepatocarcinogenesis [176].