For example, Takamura et al. [172] found several years ago that in mice hepatocyte-specific silencing of essential genes relevant to autophagy, such as Autophagy-related 5 (Atg5) and 7 (Atg7) [166, 173], stimulated hepatomegaly and the formation of adenomas but not HCCs. This evidence concerns the gene ATG5 and adenoma.