A recent survey focusing on current practice for diagnosis and management of patients with unclassified bleeding disorders in United Kingdom [31] showed that only 37% and 2% of the centres assayed PAI-1 and/or alpha-2-antiplasmin or performed euglobulin clot lysis time respectively to exclude other disorders before making a diagnosis of an unclassified bleeding disorder in a patient with a significant bleeding history. Here, SERPINE1 is linked to hemorrhagic disease.