The Venn diagram yielded eight TRIM genes with significant overexpression in gliomas compared to normal brain tissue from each of the three datasets: TRIM2, TRIM3, TRIM17, TRIM25, TRIM27, TRIM28, TRIM35, and TRIM56. To further screen for candidate TRIM genes, we performed Kaplan–Meier survival analysis on these eight genes in GEPIA2 (Figure S1c) and found that TRIM3 and TRIM56 expression correlated with overall survival in GBM patients. This evidence concerns the gene TRIM2 and central nervous system cancer.