We found that cIAP1 and TRIM56 were both highly expressed in glioma cells, and that the expression of cIAP1, but not A20, was significantly decreased with knockdown of TRIM56 in GBM#P3-, LN229- and U118MG-sh-TRIM56-S1 and -S2 cells (Fig. 4c). This evidence concerns the gene TNFAIP3 and central nervous system cancer.