Tumor size was significantly reduced for GBM#P3- and LN229-sh-TRIM56 xenografts relative to controls on the 28th day after implantation (GBM#P3, P1 < 0.0001, P2 < 0.0001; LN229, P1 < 0.01, P2 < 0.001; Fig. 3a-b and S5a-b), while the body weight of the mice was increased to some extent relative to control animals (GBM#P3, P1 < 0.0001, P2 < 0.0001; LN229, P1 < 0.0001, P2 < 0.0001; Fig. 3c and S5c). The gene discussed is TRIM56; the disease is neoplasm.