Notably, cisplatin treatment significantly promoted the expression of these cytokines in GFP-knockdown but not Hotair-knockdown cells (Fig. 5c, d, e), indicating that knockdown of Hotair abolished cisplatin-induced upregulation of IL-6, TNF-α, and IL-1β in mouse bladder cancer cells. The gene discussed is IL6; the disease is urinary bladder carcinoma.