We also show that MBT-2 tumor-derived CM upregulated the expression of atrophy-related E3 ubiquitin ligases MuRF-1, UBR2, and atrogin-1 in C2C12 cells, which could be downregulated by Hotair knockdown (Fig. 6g, h). The gene discussed is FBXO32; the disease is neoplasm.