Since we did not have the mouse Hotair expression vector, and MBT-2 cells express elevated levels of Hotair and therefore are not suitable for overexpression experiments, we were unable to manipulate Hotair overexpression in mouse bladder cancer cells for demonstrating the reversibility of animal results using Hotair-knockdown MBT-2 cells (Fig. 7). This evidence concerns the gene HOTAIR and urinary bladder cancer.