Our meta-analysis confirms that MIS-C has specific characteristics compared to KD, including being more common in older patients, more frequent respiratory and gastrointestinal involvement, shock, more cardiac complications (myocarditis, LV dysfunction, valvular regurgitation, pericardial effusion and pericarditis), fewer conjunctivitis symptoms, higher levels of inflammatory markers (CRP, D-dimer, fibrinogen and ferritin), myocardial injury markers (NT-proBNP, troponin, AST) and creatine, and lower levels of lymphocyte count, PLT count, albumin, ALT and ESR. The gene discussed is NPPB; the disease is conjunctivitis.