Generally, OBC is characterized by favorable biological features, including a low tumor grade, low lympho-vascular invasion, histological types with good prognoses, more expressions of ER and PR, diploid and B-cell lymphoma 2 (Bcl-2) protein, and lesser expressions of HER2, Ki67, p53, and epidermal growth factor receptor [5, 14, 16, 20–30]. This evidence concerns the gene ESR1 and neoplasm.