For example, in this study, HGGs were more likely to have MGMT-um and IDH-wt than LGGs (P = 0.002 and P < 0.0001, respectively), and consequently, the ADC values in MGMT-unmethylated gliomas might be affected by the tumor grading and concurrent IDH-wt. The gene discussed is IDH1; the disease is central nervous system cancer.