BRD2 and Premature ovarian insufficiency: Premature ovarian insufficiency (POI), also known as primary ovarian insufficiency, is a clinical syndrome associated with the loss of ovarian function in women before 40 years of age, characterized by amenorrhea or menstrual irregularity for more than four months, hypoestrogenism and hypergonadotropism (two serum follicle-stimulating hormone (FSH) levels obtained at least 4 weeks apart > 25 IU/L) [1].