APP and Alzheimer disease: To determine how Aβ deposits impact hippocampal dynamic calcium activity and LFP rhythms and their coordination across the distinct brain states that underlie memory encoding and consolidation, here we acquired large scale dynamic calcium imaging in hippocampal CA1 neurons with the head-mounted miniscope (InscopixTM) in concert with concomitant cortical and hippocampal LFP recordings across the sleep–wake cycle of aged APPswe/PS1dE9 (APP/PS1) transgenic mice, an AD model that recapitulates Aβ plaque formation and hippocampal-dependent memory impairments14.