We show that ERAS is triggered by ER stress induced by expression of the ERAD substrates CPL-1* and ATM, treatment with tunicamycin/thapsigargin, or viral infection (Figs. 2c,d,g,i, 3a–c, 4c,k and 5 and Extended Data Figs. 2, g and 3c). The gene discussed is ERAS; the disease is viral infectious disease.