Except for one NF1-mutated pediatric tumor (Fig. 1b), which was associated with a stronger MES-like signature as previously reported33,39, we did not detect any additional recurring genetic mutations in coding gene regions in tumors enriched for MES-like cells, suggesting either non-coding mutations and/or non-genetic determinants may underlie the observed age-specificity. The gene discussed is NF1; the disease is neoplasm.