Most interesting are missense variants of high allele frequency but decreased risk for asthma and allergic rhinitis (Fig S4 until Fig S10) where primarily VOI in IL1RL1 (IL33 receptor), PGAP3 (a phospholipase), IKZF3 (B cell transcription factor), ZPBP2 (zona pellucida binding protein) and GSDMB (gasdermin) are interesting as they have been identified already in earlier association studies. The gene discussed is IKZF3; the disease is asthma.