IL11 and acute kidney injury: To determine whether a neutralizing IL11 antibody (X203)24,31,32 impacts pEMT pathways and preserves kidney structure and function following severe AKI, we first explored effects of a range of X203 concentrations (0.5–10 mg/kg, as compared to IgG) on renal phenotypes in a preemptive administration mode (Fig. 3a).