Notably, GPR183, which has been reported to be involved in the migration, expansion, and infiltration of B cells and T follicular helper cells (Tfh)38,39, showed high expression in dermal T_SC0 (Fig. 5h), suggesting that this T cell subset may be related to B cell accumulation and ectopic germinal center formation in cutaneous lesions of DLE and SLE. The gene discussed is GPR183; the disease is systemic lupus erythematosus.