IFNG and systemic lupus erythematosus: The results showed that epidermal B cells in HC were involved in RNA catabolic processes and T cell activation, while epidermal B cells in DLE and SLE were involved in more BPs, including the type I interferon signaling pathway, response to virus, response to interferon gamma, regulation of innate immune response, neutrophil activation involved in immune response and leukocyte cell-cell adhesion (Fig. 6e).